Telechelic alkadiene polymers with crosslinkable end groups and methods for making the same

ABSTRACT

The present invention relates to telechelic polymers having crosslinkable end groups of the formula                    
     and methods for preparing the same wherein n is an integer;                    
     is an alkadienyl group; Y is an alkyl group; and Z is crosslinkable end group. In general, the inventive synthesis involves reacting a functionalized chain transfer agent having crosslinkable ends with a cycloalkene in the presence of a ruthenium or osmium catalyst of the formula                    
     wherein: 
     M is ruthenium or osmium; 
     X and X 1  are independently any anionic ligand; 
     L and L 1  are any neutral electron donor ligand; 
     R and R 1  are each hydrogen or a substituted or unsubstituted substituent wherein the substituent is selected from the group consisting of C 1 -C 20  alkyl, C 2 -C 20  alkenyl, C 2 -C 20  alkynyl, aryl, C 1 -C 20  carboxylate, C 1 -C 20  alkoxy, C 2 -C 20  alkenyloxy, C 2 -C 20  alkynyloxy, aryloxy, C 2 -C 20  alkoxycarbonyl, C 1 -C 20  alkylthio, C 1 -C 20  alkylsulfonyl and C 1 -C 20  alkylsulfinyl. In another aspect of the invention, methods for controlling the molecular weight of the resulting telechelic polymer are also presented.

This application claims the benefit of and incorporates by reference herein U.S. Provisional Application No. 60/079,949 filed Mar. 30, 1998 entitled TELECHELIC ALKADIENE POLYMERS WITH CROSS-LINKABLE END GROUPS AND METHODS FOR MAKING THE SAME by inventors Bob Robinson Maughon, Takeharu Morita; and Robert H. Grubbs.

The U.S. Government has certain rights in this invention pursuant to Grant No. CHE-9509745 awarded by the National Science Foundation.

BACKGROUND

The present invention relates to telechelic polymers and methods for making the same. More particularly, the present invention relates to telechelic polymer segments of controlled molecular weight having crosslinkable end groups and methods for preparing the same.

Telechelic polymers can be simply defined as polymers that bear reactive functional groups at their chain termini. The interest in these polymeric materials is derived from the fact that through these reactive end groups, a vast number of macromolecular materials can be prepared. Telechelic polymers have found application in the synthesis of block copolymers, star polymers, cross-linked polymer networks, and ionic polymer networks. Low molecular weight liquid telechelic polymers have been successfully used in reaction injection molding, and the formation of ABA triblock and multiblock copolymers via telechelic polymers has dramatically impacted the development of thermoplastic elastomers. Based on these numerous valuable applications, considerable research efforts have been devoted to improving the synthesis of telechelic polymers.

The development of telechelic polymers with crosslinkable end groups such as methacrylate or epoxide groups is of interest for the preparation of interpenetrating polymer networks, AB cross-linked polymeric materials, more thermally and chemically resistant materials, and for the immobilization of biomaterials. However, these reactive end groups have been typically incorporated through a post-polymerization transformation due to the instability of these functional groups to tolerate many of the typical conditions associated with polymerization reactions.

Recently, a non-metathesis-mediated polymer degradation approach was applied to polymers derived from ROMP. Copolymerization of cyclooctadiene (“COD”) with either cis-4,7-dihydro-1,3-dioxepan (1) or cis-4,7-dihydro-2-phenyl-1,3-dioxepan (2) using well-defined ruthenium-based metathesis initiators, (PCy₃)Cl₂Ru═CHR′ (wherein R′=Ph (3)or wherein R′=(CH═CPh₂)(4)), resulted in a polymer bearing both poly(butadiene) and acetal units along the backbone. Subsequent acid hydrolysis of these acetal units resulted in the desired hydroxytelechelic poly(butadiene) (“HTPBD”) oligomers in moderate yields. Although this method proved to be successful for the synthesis of HTPBD, this method is not generally applicable for the preparation of telechelic polymers with other functional end groups.

As a result, a need exists for methods for synthesizing telechelic polymers having a variety of end groups, particularly crosslinkable end groups and which does not require post-polymerization transformations for polymer functionalization.

SUMMARY OF THE INVENTION

The present invention relates to telechelic polymers having crosslinkable end groups of the formula

and methods for preparing the same wherein n is an integer

is an alkadienyl group; Y is an alkyl group; and Z is crosslinkable end group. In general , the inventive synthesis involves reacting a chain transfer agent having crosslinkable end groups with a cycloalkene in the presence of a ruthenium or osmium initiator of the formula

wherein:

M is ruthenium or osmium;

X and X¹ are independently any anionic ligand;

L and L¹ are any neutral electron donor ligand;

R and R¹ are each hydrogen or a substituted or unsubstituted substituent wherein the substituent is selected from the group consisting of C₁-C₂₀ alkyl, C₂-C₂₀ alkenyl, C₂-C₂₀ alkynyl, aryl, C₁-C₂₀ carboxylate, C₁-C₂₀ alkoxy, C₂-C₂₀ alkenyloxy, C₂-C₂₀ alkynyloxy, aryloxy, C₂-C₂₀ alkoxycarbonyl, C₁-C₂₀ alkylthio, C₁-C₂₀ alkylsulfonyl and C₁-C₂₀ alkylsulfinyl.

In particularly preferred embodiments, the initiator is as described above wherein R is hydrogen, R¹ is phenyl or (—CH═CPh₂), X and X¹ are both chloride, and L and L¹ ligands are —P(cyclohexyl)₃; the cycloalkene is cyclooctadiene; and the chain transfer agent is cis-2-butene-1,4-diol dimethacrylate or cis-2-butene-1,4-diol diglycidyl ether.

BRIEF DESCRIPTION OF THE FIGURES

FIG. 1 is an illustrative reaction scheme for the synthesis of a telechelic polymer with methacrylate end groups.

FIG. 2 is graphic representation of the dependence of the observed {overscore (M)}_(n) values for the bis(methacrylate)-functionalized telechelic poly(butadiene)s 9 on the [COD]/[CTA] ratio. The {overscore (M)}_(n) was determined by ¹H NMR integration assuming a number average functionality of 2.0.

FIG. 3 is a graphic representation of the dependence of the observed {overscore (M)}_(n) values for the bis(epoxide)-functionalized telechelic poly(butadiene)s 10 on the [COD]/[CTA] ratio. The {overscore (M)}_(n) was determined by ¹H NMR integration assuming a number average functionality of 2.0.

DESCRIPTION OF THE PREFERRED EMBODIMENTS

The present invention relates to novel organic polymers with crosslinkable end groups and to a simplified and direct procedure for the synthesis of these polymers. These crosslinkable end groups may be subsequently reacted to form a network of crosslinked polymers.

The present invention relates to unbranched or linear telechelic polymers of the general formula

wherein:

n is an integer;

 is a alkadienyl group;

Y is an alkyl group; and,

Z is a crosslinkable end group.

As used herein, an alkadienyl group is a hydrocarbon having at least two carbon—carbon double bonds. In preferred embodiments,

is a C₄-C₂₀ alkadienyl group; Y is a C₁-C₁₀ alkyl and Z is selected from the group consisting of methacrylate, acylate, cinnamate, epoxide, lactone, cyclic carbonate, tetrahydrofuran, oxetane, lactams, phosphazenes, and alkoxysilanes. In more preferred embodiments, Y is a C₁-C₃ alkyl and Z is methacrylate or epoxide.

In another aspect of the present invention, telechelic polymers of the formula

are disclosed wherein:

n is an integer;

 is an alkadienyl group; and,

Z is a crosslinkable end group.

In preferred embodiments,

is a C₄-C₂₀ alkadienyl group and Z is selected from the group consisting of methacrylate, acylate, cinnamate, epoxide, lactone, cyclic carbonate, tetrahydrofuran, oxetane, lactams, phosphazenes, and alkoxysilanes. In more preferred embodiments, Z is methacrylate or epoxide.

In yet another aspect of the present invention, telechelic polymers of the formula

wherein n is an integer and Z is a crosslinkable end group. In preferred embodiments, Z is selected from the group consisting of methacrylate, acylate, cinnamate, epoxide, lactone, cyclic carbonate, tetrahydrofuran, oxetane, lactams, phosphazenes, and alkoxysilanes. In more preferred embodiments, Z is methacrylate or epoxide.

In another embodiment of the present inventions, methods for synthesizing the above disclosed telechelic polymers are disclosed.

Initiators

In general, initiators (or catalysts) that may be used in the practice of the present invention are ruthenium or osmium carbene complexes that include a ruthenium or osmium metal center that is in a +2 oxidation state, have an electron count of 16, and are penta-coordinated. More specifically, the initiators are of the formula

wherein:

M is ruthenium or osmium;

X and X¹ are independently any anionic ligand;

L and L¹ are any neutral electron donor ligand;

R and R¹ are each hydrogen or one of the following substituent groups: C₁-C₂₀ alkyl, C₂-C₂₀ alkenyl, C₂-C₂₀ alkynyl, aryl, C₁-C₂₀ carboxylate, C₁-C₂₀ alkoxy, C₂-C₂₀ alkenyloxy, C₂-C₂₀ alkynyloxy, aryloxy, C₂-C₂₀ alkoxycarbonyl, C₁-C₂₀ alkylthio, C₁-C₂₀ alkylsulfonyl and C₁-C₂₀ alkylsulfinyl. Optionally, the substituent group may be substituted with one or more groups selected from C₁-C₅ alkyl, C₁-C₅ alkoxy, and aryl. When the substitute aryl group is phenyl, it may be further substituted with one or more groups selected from a halogen, a C₁-C₅ alkyl, or a C₁-C₅ alkoxy. Moreover, the initiator may further include one or more functional groups. Examples of suitable functional groups include but are not limited to: hydroxyl, thiol, thioether, ketone, aldehyde, ester, ether, amine, imine, amide, nitro, carboxylic acid, disulfide, carbonate, isocyanate, carbodiimide, carboalkoxy, carbamate, and halogen.

These ruthenium and osmium carbene complexes have been described in U.S. Pat. Nos. 5,312,940, 5,342,909, 5,710,298, and 5,831,108 and PCT Publication No. WO 98/21214, all of which are incorporated herein by reference.

In preferred embodiments of these catalysts, the R substituent is hydrogen and the R¹ substituent is selected from the group consisting C₁-C₂₀ alkyl, C₂-C₂₀ alkenyl, and aryl. In even more preferred embodiments, the R¹ substituent is phenyl or vinyl, optionally substituted with one or more moieties selected from the group consisting of C₁-C₅ alkyl, C₁-C₅ alkoxy, phenyl, and a functional group. In especially preferred embodiments, R¹ is phenyl or vinyl substituted with one or more moieties selected from the group consisting of chloride, bromide, iodide, fluoride, —NO₂, —NMe₂, methyl, methoxy and phenyl. In the most preferred embodiments, the R¹ substituent is phenyl.

In preferred embodiments of these catalysts, L and L¹ are each independently selected from the group consisting of phosphine, sulfonated phosphine, phosphite, phosphinite, phosphonite, arsine, stibine, ether, amine, amide, imine, sulfoxide, carboxyl, nitrosyl, pyridine, and thioether. In more preferred embodiments, L and L¹ are each a phosphine of the formula PR³R⁴R⁵, where R³, R⁴, and R⁵ are each independently aryl or C₁-C₁₀ alkyl, particularly primary alkyl, secondary alkyl or cycloalkyl . In the most preferred embodiments, L and L¹ ligands are each selected from the group consisting of —P(cyclohexyl)₃, —P(cyclopentyl)₃, —P(isopropyl)₃, and —P(phenyl)₃.

In preferred embodiments of these catalysts, X and X¹ are each independently hydrogen, halide, or one of the following groups: C₁-C₂₀ alkyl, aryl, C₁-C₂₀ alkoxide, aryloxide, C₃-C₂₀ alkyldiketonate, aryldiketonate, C₁-C₂₀ carboxylate, arylsulfonate, C₁-C₂₀ alkylsulfonate, C₁-C₂₀ alkylthio, C₁-C₂₀ alkylsulfonyl, or C₁-C₂₀ alkylsulfinyl. Optionally, X and X¹ may be substituted with one or more moieties selected from the group consisting of C₁-C₁₀ alkyl, C₁-C₁₀ alkoxy, and aryl which in turn may each be further substituted with one or more groups selected from halogen, C₁-C₅ alkyl, C₁-C₅ alkoxy, and phenyl. In more preferred embodiments, X and X¹ are halide, benzoate, C₁-C₅ carboxylate, C₁-C₅ alkyl, phenoxy, C₁-C₅ alkoxy, C₁-C₅ alkylthio, aryl, and C₁-C₅ alkyl sulfonate. In even more preferred embodiments, X and X¹ are each halide, CF₃CO₂, CH₃CO₂, CFH₂CO₂, (CH₃)₃CO, (CF₃)₂(CH₃)CO, (CF₃)(CH₃)₂CO, PhO, MeO, EtO, tosylate, mesylate, or trifluoromethanesulfonate. In the most preferred embodiments, X and X¹ are each chloride.

The most preferred initiators in the practice of the present invention are as described above wherein M is ruthenium; X and X¹ are both chloride; L and L¹ ligands are both —P(cyclohexyl)₃; R is hydrogen; and R¹ is either phenyl (3), (—CH═CPh₂) (4), or (CH═C(CH₃)₂).

The above initiators are stable in the presence of a variety of functional groups including hydroxyl, thiol, ketone, aldehyde, ester, ether, amine, imine, amide, nitro, carboxylic acid, disulfide, carbonate, isocyanate, carbodiimide, carboalkoxy, and halogen. Therefore, the starting materials and products of the reactions described below may contain one or more of these functional groups without poisoning the catalyst. In addition, the initiators are stable in the presence of aqueous, organic, or protic solvents, including aromatic hydrocarbons, chlorinated hydrocarbons, ethers, aliphatic hydrocarbons, alcohols, water, or mixtures of the above.

Using an initiator described above, practice of one embodiment of the inventive method may be summarized as follows:

wherein:

n is an integer;

is a cycloalkene;

Z—Y═Y—Z is a chain transfer agent wherein Z is a crosslinkable end group and —Y═Y— is an alkenyl group; and,

is the resulting telechelic polymer.

Any cycloalkene (also referred to as cyclic olefin) that can participate in a ring- opening metathesis polymerization (“ROMP”) reaction may be used. Because of the generally high metathesis activity of the initiators of the present invention, the cycloalkene may be strained or unstrained. In addition, the cycloalkene may include one or more substituent groups selected from the group consisting of C₁-C₁₀ alkyl, C₂-C₁₀ alkenyl, C₂-C₁₀ alkynyl, and aryl and one or more functional groups selected from the group consisting of hydroxyl, thiol, thioether, ketone, aldehyde, ester, ether, amine, imine, amide, nitro, carboxylic acid, disulfide, carbonate, isocyanate, carbodiimide, carboalkoxy, carbamate, and halogen.

Illustrative examples of suitable cycloalkenes include but are not limited to: norbornene, norbornadiene, cyclopentene, dicyclopentadiene, cyclo-octene, 7-oxanorbornene, 7-oxanorbornadiene, cyclodocene, 1,3-cyclooctadiene, 1,5-cyclooctadiene, 1,3-cycloheptadiene, and derivatives thereof. In preferred embodiments, the cycloalkene is a cycloalkadiene. In more preferred embodiments, the cycloalkene is selected from the group consisting of norbornadiene, dicyclopentadiene, 1,3-cyclo-octadiene, 1,5-cyclo-octadiene, 1,3-cycloheptadiene, and derivatives thereof. The use of 1,3-cyclooctadiene or 1,5-cyclo-octadiene as the cycloalkene is most preferred.

The chain transfer agent (“CTA”) is of the general formula, Z—Y═Y—Z, wherein —Y═Y— is an alkenyl group and Z is a crosslinkable end group. As used herein, a crosslinkable end group is group that is capable of forming a covalent bond either by reacting directly with another crosslinkable end group or by reacting indirectly through a crosslinking agent with another crosslinkable end group.

In preferred embodiments, —Y═Y— is a C₂-C₂₀ alkene and Z is selected from a group consisting of methacrylate, acylate, cinnamate, epoxide, lactone, cyclic carbonate, tetrahydrofuran, oxetane, lactams, phosphazenes, and alkoxysilanes. In more preferred embodiments, —Y═Y— is a C₂-C₁₀ alkenyl and Z is methacrylate or epoxide. In the most preferred embodiments, the chain transfer agent is cis-2-butene- 1,4-diol dimethacrylate (5) or cis-2-butene- 1,4-diol diglycidyl ether (6).

In another embodiment, the inventive method may be summarized as follows:

wherein

n is an integer;

 is a cycloalkene;

 is a chain transfer agent wherein Z is a crosslinkable end group; and,

 is the resulting telechelic polymer.

In preferred embodiments, the cycloalkene is selected from a group consisting of norbornene, norbornadiene, cyclopentene, dicyclopentadiene, cyclo-octene, 7-oxanorbornene, 7-oxanorbornadiene, cyclodocene, 1,3-cyclooctadiene, 1,5-cyclooctadiene, 1,3-cycloheptadiene, and derivatives thereof, and Z is selected from the group consisting of methacrylate, acylate, cinnamate, epoxides, lactone, cyclic carbonate, tetrahydrofuran, oxetane, lactams, phosphazenes, and alkoxysilanes.

In more preferred embodiments, the cycloalkene is a cycloalkadiene. In especially preferred embodiments, the cycloalkene is selected from the group consisting of norbornadiene, dicyclopentadiene, 1,3-cyclo-octadiene, 1,5-cyclo-octadiene, 1,3-cycloheptadiene, and derivatives thereof, and Z is methacrylate or epoxide. The use of 1,3-cyclooctadiene or 1,5-cyclo-octadiene as the cycloalkene, and cis-2-butene-1,4-diol dimethacrylate (5) or cis-2-butene-1,4-diol diglycidyl ether (6) as the chain transfer agent is most preferred.

In another embodiment, the inventive method may be described as follows:

wherein n is an integer and Z is a crosslinkable end.

In preferred embodiments, Z is selected from the group consisting of methacrylate, acylate, cinnamate, epoxides, lactone, cyclic carbonate, tetrahydrofuran, oxetane, lactams, phosphazenes, and alkoxysilanes. In the most preferred embodiments, Z is either

In addition to the ease of synthesis, the practice of the molecular weight of the telechelic polymer product may be readily controlled by modulating the ratio of the cycloalkene concentration to the chain transfer agent concentration. In a surprising and unexpected finding, the molecular weight of the resulting polymer is directly proportional to the molecular weight of the resulting telechelic polymer. As a result, by modulating the starting materials in the form of a [cycloalkene]/[chain transfer agent] ratio, the telechelic polymers having the desired molecular weight may be synthesized.

For the purposes of clarity, the specific details of the present invention will be illustrated with reference to especially preferred embodiments wherein the initiator is 3 or 4, the cycloalkene is cyclooctadiene, and the chain transfer agent is cis-2-butene-1,4-diol dimethacrylate (5) or cis-2-butene-1,4-diol diglycidyl ether (6). However, it should be appreciated that these embodiments and the appended experimental protocols are for purposes of illustration only and are not intended to limit the scope of the present invention.

Synthesis of the cis-2-Butene-1,4-diol Dimethacrylate

Synthesis of the bis(methacrylate)-functionalized chain transfer agent, cis-2-butene-1,4-diol dimethacrylate (5), was accomplished as shown in Scheme 1.

Commercially available cis-2-butene-1,4-diol was esterified using methacryloyl chloride to synthesize compound 5 in 72% yield. Because compound 5 was not generally stable, it was stored at −30° C. with 20 weight percent of p-methoxyphenol (a free radical inhibitor). In this manner, compound 5 was stored for over six months without any appreciable degradation or polymerization. Because of the general tolerance of initiators 3 and 4, compound 5 could be used without removing p-methoxyphenol prior to its used in polymerization reactions.

Synthesis of the cis-2-Butene- 1 ,4-diol Diglycidyl Ether

The synthesis of the bis(epoxide)-functionalized chain transfer agent, cis-2-butene-1,4-diol diglycidyl ether (6), was accomplished in one step as illustrated in Scheme 2.

Cis-2-butene- 1,4-diol was treated with excess epichlorohydrin in the presence of aqueous NaOH (50% w/w) and the phase transfer catalyst, Bu₄N⁺HSO₄ ⁻, to resulted in chain transfer agent 6 in 65% yield. Because compound 6 was extremely stable, it was purified by distillation at 105-110° C. in vacuo. Samples of compound 6 stored at room temperature for over six months, exhibited virtually no decomposition or polymerization.

Reaction of CTAs 5 and 6 with the Ruthenium Benzylidene Initiator 3

As shown by FIG. 1, the generation of an end group functionalized ruthenium alkylidene species is a key step in the practice of the present invention. However, it was initially unclear whether a ROMP-type protocol using a chain transfer agent, Z—Y═Y—Z, would be a viable synthetic strategy. Previous mechanistic studies indicated that ruthenium-based metathesis initiators including 3 and 4 were susceptible to a side reaction where the functional end group (e.g. from a chain transfer agent) would chelate to the metal center with a concomitant loss of a L ligand (typically a phosphine). The resulting chelated species were less reactive and often decomposed on the time scale of a typical polymerization reaction. Consequently, whether reactions of ruthenium benzylidene 3 with both 5 and 6 would proceed according to Scheme 4 were investigated.

Unexpectedly, treatment of 3 with 50 equivalents of the bis(methacrylate)-functionalized CTA 5 at 45° C. for 30 min resulted in the formation of a methacrylate-functionalized ruthenium alkylidene 7 as outlined by Scheme 4. Alkylidene 7 exhibited an α-H carbene resonance at 19.48 ppm (t, J_(HH)=4.4 Hz) in the ¹H NMR and a ³¹P resonance at 37.42 ppm with no observed free phosphine. Moreover, alkylidene 7 showed no decomposition over 24 hours at room temperature.

Similarly, treatment of 3 with 50 equivalents of the bis(epoxide)-functionalized CTA 6 at 45° C. for 30 min resulted in the formation of an epoxide-functionalized ruthenium alkylidene 8. This alkylidene exhibited an α-H carbene resonance at 19.79 ppm (t, J_(HH)=3.6 Hz) in the ¹H NMR and a ³¹P resonance at 36.91 ppm with no observed free phosphine. Decomposition of alkylidene 8 was not observed even after being stored for 24 hours at room temperature. As a result, the lack of observed free phosphine and the ¹H and ³¹P resonances indicated that telechelic polymers with crosslinkable end groups may be synthesized using ROMP in the presence of a chain transfer agent of the general formula Z—Y═Y—Z.

Polymerization of COD in the Presence of 5

In the presence of the CTA 5, polymerization of COD resulted in the bis(methacrylate)-functionalized telechelic poly(butadiene) 9 as shown in Scheme 5.

In an initial study, the impact of the [COD]/[3] ([COD]/[initiator]) ratio, reaction time, and temperature on the polymer yield and CTA incorporation was investigated. The polymerizations were run neat according to the different sets of conditions described in Table 1.

In the first two entries, reaction time and temperature were held constant at 24 h and 25° C. while the [COD]/[initiator] ratio was increased from 2000:1 to 4000:1. Although only a slight decrease in the yield of 5% was observed, the {overscore (M)}_(n) increased from 3500 to 5500 presumably due to a reduced incorporation of the CTA 5 during the polymerization. The impact of reaction time was investigated by comparing the results for reaction times of 24 and 48 hours (at: [COD]/[5]=10; [COD]/[initiator]=2000; and a temperature of 25° C.). As seen in the third and fourth entries, increasing the reaction time resulted in a slight increase in yield and a lower molecular weight due to an improved incorporation of 5. Unfortunately, the impact of temperature was unable to be investigated because of the relative instability of 5. For example, presumably due to the thermally-induced polymerization of the methacrylate groups, insoluble polymeric materials were formed when polymerizations were run at 45° C.

Based on these results, all COD polymerization reactions with 5 were run with a [COD]/[initiator] ratio of 2000:1 for 48 hours at 25° C. In addition, efforts were taken to minimize photo-induced polymerization of the methacrylate groups by shielding the reaction vesicle from light.

TABLE 1 [COD]/ Rxn. [COD]/ [init- Time Temp. {overscore (M)}_(n) {overscore (M)}_(n) [5] iator] (h) (° C.) % Yield^(a) (Theoretical)^(b) (NMR)^(c) 15 2000 24 25 80 1844 3500 15 4000 24 25 75 1844 5500 10 2000 24 25 85 1304 2500 10 2000 48 25 87 1304 2300 ^(a)Isolated yields after purification. ^(b)Determined by ([COD]/[5])(MW of COD) + (MW of 5). ^(c)Determined by ¹H NMR integration assuming a number average functionality of 2.

Practice of the present invention is extremely advantageous because of the ability to control the polymer molecular weights through the manipulation of the [monomer]/[CTA] ratio. A series of bis(methacrylate)-functionalized telechelic poly(butadiene)s were synthesized with [COD]/[5] ratios of 15, 40, 60, and 80:1. As shown by Table 2, yields between 88-90% were obtained, and the molecular weight was indeed controlled resulting in bis(methacrylate)-functionalized telechelic poly(butadiene)s with {overscore (M)}_(n) values between 3700 to 17700.

TABLE 2 % Cis- % Cis- Olefin [COD] % Olefin (End {overscore (M)}_(n) {overscore (M)}_(n) /[5] Yield^(d) (Backbone)^(e) Group)^(e) (NMR)^(f) (GPC)^(g) PDI^(h) 15^(a) 88 50 25 3700 5400 1.74 40^(a) 89 55 20 8000 10100 1.86 60^(b) 90 60 25 14500 11900 2.02 80^(c) 90 55 25 17700 15300 1.99 ^(a)Polymerizations were run neat at 25° C. for 48 h with [COD]/[initiator] = 2000. ^(b)To ensure better mixing and higher yields, [COD] = 12.4M in benzene was utilized. ^(c)To ensure better mixing and higher yields, [COD] = 9.3M in benzene was utilized. ^(d)Isolated yields after purification. ^(e)Determined by ¹H NMR integration. ^(f)Determined by ¹H NMR integration assuming a number average functionality of 2. ^(g)Determined by gel permeation chromatography in CH₂Cl₂ relative to monodispersed polystyrene standards.

As illustrated in the plot of {overscore (M)}_(n) versus the [COD]/[5] ratio in FIG. 1, a direct correlation was observed between the [COD]/[5] ratio and polymer molecular weight. Although the experimentally observed molecular weights were higher than that calculated for the theoretical molecular weights, this is believed to be due to the incomplete incorporation of the chain transfer agent 5 during the polymerization.

The resulting telechelic poly(butadiene)s contained between 50-60% cis-olefin in the backbone and between 20-25% cis-olefin at the polymer end groups, and polydispersities (PDIs) of 1.74-2.02 were obtained. Both ¹H and ¹³C NMR indicated a {overscore (F)}_(n) value near 2.

Polymerization of COD in the Presence of 6

Polymerization of COD in the presence of the chain transfer agent 6 resulted in bis(epoxide)-functionalized telechelic poly(butadiene) 10 as shown in Scheme

The impact of the [COD]/[CTA] ratio, reaction time, and temperature on the polymer yield and the incorporation of 6 was examined. All polymerization reactions were run neat according to the conditions described in Table 3.

TABLE 3 [COD]/ Rxn. Temp. {overscore (M)}_(n) [COD]/[6] [initiator] Time (h) (° C.) % Yield^(a) (NMR)^(b) 15 2000 48 25 60 3700 15 4000 48 25 51 3600 15 2000 24 45 67 3400 15 2000 48 45 67 3400 15 4000 24 45 63 3500 15 4000 48 45 61 3700 ^(a)Isolated yields after purification. ^(b)Determined by ([COD]/[6])(MW of COD) + (MW of 6). ^(b)Determined by ¹H NMR integration assuming a number average functionality of 2.

Despite similar molecular weight values, a lower yield (51% compared to 60%) was observed at the lower initiator loading. As a result, polymerization reactions in the presence of 6 were run at 25° C. and at a 2000:1 [COD]/[initiator] ratio. However, unlike the polymerization of COD in the presence of 5, polymerization reactions could be run at higher temperatures because of the relative stability of 6. Comparing entries 3-6 in Table, similar yields and molecular weights were observed regardless of changes in the reaction time or the [COD]/[initiator] ratio. Therefore, based on these results, all COD polymerization reactions in the presence of chain transfer agent 6 were carried out at 45° C. with a [COD]/[initiator] ratio of 4000:1 for 24 hours.

The effect of the [COD][CTA] ratio was also investigated. By varying the [COD]/[6] ratio from 15 to 80: 1, {overscore (M)}_(n) values between 3000-16800 were obtained with yields between 71-87% (see Table 4).

TABLE 4 % Cis- % Cis- Olefin [COD] % Olefin (End {overscore (M)}_(n) {overscore (M)}_(n) /[6] Yield^(d) (Backbone)^(e) Group)^(e) (NMR)^(f) (GPC)^(g) PDI^(g) 15^(a) 71 60 30 3000 4000 1.55 40^(a) 80 65 25 7800 6900 1.89 60^(b) 87 50 30 11000 10500 1.87 80^(c) 84 55 25 16800 11600 1.94 ^(a)Polymerizations were run neat at 45° C. for 24 h with [COD]/[initiator] = 4000. ^(b)To ensure better mixing and higher yields, [COD] = 12.4M in benzene was utilized. ^(c)To ensure better mixing and higher yields, [COD] = 9.3M in benzene was utilized. ^(d)Isolated yields after purification. ^(e)Determined by ¹H NMR integration. ^(f)Determined by ¹H NMR integration assuming a number average functionality of 2. ^(g)Determined by gel permeation chromatography in CH₂Cl₂ relative to monodispersed polystyrene standards.

As shown by FIG. 3, an excellent correlation was observed between the [COD]/[6] and polymer molecular weight (M n). The bis(epoxide)-functionalized telechelic poly(butadiene)s 10 contained between 50-65% cis-olefins in the backbone and between 25-30% cis-olefins in the end groups. The observed PDIs ranged from 1.55 to 1.94. Both ¹H and ¹³C NMR indicated a {overscore (F)}_(n) near 2 for these materials.

Cross-linking of the Telechelic Poly(Butadiene)s 9 and 10

Crosslinking studies of the telechelic poly(butadiene)s 9 and 10 were conducted. Bis(methacrylate)-functionalized telechelic poly(butadiene)s 9 was crosslinked using both thermal and photochemical methods. For thermal cross-linking, concentrated solutions of polymer 9 (100 mg of polymer 9 in 200 μL toluene) ({overscore (M)}_(n) values between 3700 to 17700) were combined with benzoyl peroxide (2 wt %) and heated to 90° C. Within 5 minutes, a tacky insoluble material was observed, and within 15 minutes, a rubbery polymeric solid was formed which was completely insoluble in all common organic solvents including CH₂Cl₂, CHCl₃, benzene, toluene, Et₂O, ethyl acetate, and DMSO.

Photochemical crosslinking was induced by combining either benzoyl peroxide or 2,2-dimethoxy-2-phenylacetophenone (2 wt %) with the concentrated polymer solutions and photolyzing the solutions for 15 minutes using a 450 watt medium pressure mercury Hanovia lamp. As in the thermally-induced cross-linking reactions, a tacky insoluble material was formed within 5 minutes and a highly crosslinked rubbery material was obtained after 15 minute.

Bis(epoxide)-functionalized telechelic poly(butadiene)s 10 was crosslinked using an acid. Solutions of polymer 10 (100 mg of polymer 10 in 500 gL toluene) {overscore (M)}_(n) values between 3000 to 16800) were stirred with a magnetic stirrer and treated with H₂SO₄ (cat.). Upon addition of the acid, a rubbery polymeric solid was immediately observed which was insoluble in all common organic solvents including CH₂Cl₂, CHCl₃, benzene, toluene, Et₂O, ethyl acetate, and DMSO. Treatment with other acids such as HCl (1 M in Et₂O) and p-toluenesulfonic acid resulted in no significant cross-linking even at elevated temperatures. Treatment of the polymer solutions with BF₃—Et₂O (cat.) resulted in cross-linking, however the cross-linking required between 2 and 3 hours at room temperature and often gave inconsistent results. Treatment with H₂SO4 (cat.) was by far the simplest and most rapid method for the cross-linking of the bis(epoxide)-functionalized telechelic poly(butadiene)s 10.

EXPERIMENTAL METHODS General Protocols

Argon was purified by passage through columns of BASF R-11 catalyst (Chemalog) and 4 Å molecular sieves (Linde). NMR spectra were recorded on GE QE-300 Plus (300.1 MHz; 75.49 MHz ¹³C) spectrometer and a JEOL GX-400 (399.65 MHz ¹H; 100 MHz ¹³C; 161.85 MHz ³¹P) spectrometer. ³¹P NMR spectra were referenced to an external 85% H₃PO₄ standard. IR spectra were recorded on a Perkin-Elmer 1600 series FT-IR spectrometer. Gel permeation chromatographs were obtained on a HPLC system using an Altex model 110A pump, a Rheodyne model 7125 injector with a 100 μL injection loop, two American Polymer Standards 10 micron mixed bed columns, and a Knauer differential-refractometer using CH₂Cl₂ as eluent at a 1.0 mL/min flow rate. Molecular weights and polydispersities were reported versus monodispersed polystyrene standards. Photolysis was accomplished with a 450 watt medium pressure mercury Hanovia lamp.

Materials

The benzene used in polymerizations was distilled from CaH₂ under vacuum. Dry THF was obtained by distillation under atmospheric pressure from CaH₂. All other solvents were reagent grade and used without purification. cis-2-Butene-1,4-diol, methacryloyl chloride, triethylamine, NaOH, Bu₄N+HSO₄ ⁻, epichlorohydrin, p-methoxyphenol, MeOH, benzoyl peroxide, 2,2-dimethoxy-2-phenylacetophenone, BF₃Et₂O, and H₂SO₄ were purchased from the Aldrich Chemical Company and used without further purification. COD was purchased from the Aldrich Chemical Company and degassed by stirring in vacuo for 2 hours before use in polymerizations.

Preparation of cis-2-Butene-1,4-diol Dimethacrylate (5)

cis-2-Butene-1,4-diol (14.04 g, 0.16 mol, 1.0 eq) was mixed with THF (500 mL) and triethylamine (40.34 g, 0.48 mol, 3.0 eq) in a 1 L round bottom flask under argon. To the reaction flask 90% methacryloyl chloride (53.9 g, 0.46 mol, 2.9 eq) was added via an addition funnel over 1 h at 0° C. during which time a white precipitate was observed. The ice bath was then removed, and the reaction was left to stir overnight at room temperature. Deionized water (150 mL) was then added to dissolve the precipitated salts, and the reaction mixture was poured into a 2 L separatory funnel containing petroleum ether (750 mL). The organics were then washed with deionized water (3×200 mL), aqueous NaOH (15% w/w, 4×200 mL), and deionized water (3×200 mL). The organics were dried over MgSO₄ and concentrated in vacuo. The product was purified by flash column chromatography (silica gel, 5% ethyl acetate/hexanes, R_(f)=0.45) to give 26.5 g (74%) of pure product as a viscous oil. To prevent cross-linking, this material was stored with p-methoxyphenol (20 wt %) at −30° C. in a dry box. ¹H NMR (CDCl₃) δ 6.08-6.06 (m, 2H), 5.81-5.71 (m, 2H), 5.54-5.52 (m, 2H), 4.78-4.69 (m, 4H), 1.90-1.89 (m, 6H); ¹³C NMR (CDCl₃) δ 166.95; 136.03, 128.01, 125.67, 60.26, 18.19; IR (thin film on a NaCl plate) 3105, 3036, 2981, 2959, 2929, 2894, 1719, 1637, 1512, 1452, 1403, 1378, 1348, 1318, 1293, 1152, 1012, 975, 942, 815, 734, 651 cm⁻¹; HRM S (CI) calcd for C₁₂H₁₆O₄ (M+H)⁺ 225.1127, found 225.1129.

Preparation of cis-2-Butene-1,4-diol Diglycidyl Ether (6)

In a 1L Erlenmeyer flask, epichlorohydrin (270 g, 3.00 mol, 10 eq), aqueous NaOH (50% w/w) (240 g, 3.00 mol, 10 eq), and Bu₄N+HSO₄ ⁻ (5.0 g, cat.) were combined at room temperature with magnetic stirring. A thermometer was placed in the flask to monitor the temperature during the reaction. To this flask, cis-2-butene-1,4-diol (26.5 g, 0.30 mol, 1 eq) was added dropwise slowly over 30 min. The reaction was extremely exothermic, and so the temperature was maintained between 30-40° C. by controlling the addition rate as well as by intermittent cooling in an ice bath. At the end of the addition, the reaction temperature remained near 40° C. for approximately 1 h, and when it began to cool, the reaction flask was heated at 40° C. in an oil bath for an additional 1 h. The flask was allowed to cool, and then deionized water was added (200 mL). This mixture was then extracted with Et₂O (3×200 mL), dried over MgSO₄, and concentrated in vacuo to obtain a yellow oil. This was distilled at 0.2 mm Hg/105-110° C. to give a clear oil (38.0 g, 65% yield). ¹H NMR (CDCl₃) δ 5.8-5.61 (m, 2H), 4.11-4.00 (m, 4H), 3.67 (dd, J₁=3.0 Hz, J₂=11.4 Hz, 2H), 3.30 (dd, J₁=5.7 Hz, J₂=11.4 Hz, 2H), 3.11-3.06 (m, 2H), 2.73 (dd, J₁=4.2 Hz, J₂=4.8 Hz, 2H), 2.54 (dd, J₁=2.7 Hz, J₂=4.8 Hz, 2H); ¹³C NMR (CDCl₃) δ 129.13, 70.76, 66.74, 50.61, 44.03; IR (thin film on a NaCl plate) 3055, 2999, 2922, 2867, 1511, 1472, 1439, 1411, 1327, 1253, 1162, 1094, 1016, 968, 947, 901, 855, 762 cm⁻¹; HRMS (Cl) calcd for C₁₂H₁₈O₂ (M+H)⁺ 201.1127, found 201.1128.

Reaction of CTAs 5 and 6 with the Ruthenium Benzylidene (3)

All manipulations were carried out in a dry box. In a 10 mL vial, ruthenium benzylidene 3 (6.0 mg, 7.3e-6 mol, 1.0 eq), CTA (either 5 or 6) (3.7e-4 mol, 50 eq), and C₆D₆ (0.70 mL) were combined to form a homogeneous solution. This solution was transferred to a NMR tube which was capped with a rubber septa and removed from the dry box. The NMR tube was placed in an oil bath at 45° C. for 30 min. After this time, the NMR tube was removed from the oil bath, and the reaction was analyzed by both ¹H and ³¹P NMR.

General Polymerization Procedure.

All manipulations were carried out in a dry box. In a 10 mL vial, the correct amount of either 5 or 6 and COD were weighed out. In a separate vial, the initiator was weighed out and a stirbar added, and this was combined with the COD/CTA mixture. The vial was then capped, removed from the dry box, and left to stir for the desired time. For reactions involving the methacrylate CTA 5, aluminum foil was wrapped around the reaction vial to prevent photo-induced crosslinking. At the end of the desired reaction time, ethyl vinyl ether (600 eq relative to initiator) was pipetted into the vial along with an equal volume of toluene. This was left to stir for 1 h followed by precipitation into MeOH to isolate the polymer. The MeOH was decanted away, and the polymer was washed with excess fresh MeOH to remove any remaining COD or CTA. The resulting telechelic poly(butadiene)s were concentrated in vacuo and then characterized by standard methods including ¹H NMR, ¹³C NMR, IR, and GPC.

Bis(methacrylate)-functionalized Telechelic Poly(Butadiene) (9)

Spectral data for the polymer derived from a 15:1 [COD]/[5] ratio ({overscore (M)}_(n) (NMR)=3700, DP=32). ¹H NMR (CDCl₃) δ 6.13 (bs), 5.86-5.54 (bm), 4.68 (bd, J=6.0 Hz), 4.57 (bd, J=6.6 Hz), 2.43-1.72 (bm); ¹³C NMR (CDCl₃) δ 167.224, 167.14, 136.37, 135.49, 135.41, 134.50, 130.66, 130.42, 130.06, 129.94, 129.55, 129.38, 128.95, 128.76, 128.67, 125.34, 124.23, 124.14, 123.84, 123.67, 65.29, 60.60, 60.53, 32.93, 32.65, 32.28, 31.89, 27.66, 27.36, 27.01, 26.67, 18.34; IR (thin film on a NaCl plate) 3005, 2937, 2844, 1721, 1655, 1639, 1446, 1403, 1318, 1294, 1239, 1159, 1079, 1010, 966, 814, 733 cm⁻¹.

Bis(epoxide)-functionalized Telechelic Poly(Butadiene) (10)

Spectral data for the polymer derived from a 15:1 [COD]/[6] ratio ({overscore (M)}_(n) (NMR)=3000, DP=26). ¹H NMR (CDCl₃) δ 5.77-5.17 (bm), 4.09-3.91 (bm), 3.72-3.61 (bm), 3.41-3.30 (bm), 3.17-3.08 (bm), 2.81-2.72 (bm), 2.62-2.53 (bm), 2.35-1.64 (bm); ¹³C NMR (CDCl₃) δ 134.49, 134.43, 133.19, 130.26, 130.03, 129.93, 129.73, 129.52, 129.35, 126.19, 126.06, 125.90. 71.95, 70.65, 70.46, 66.81, 50.72, 44.33, 44.26, 32.91, 32.63, 32.29, 32.04, 27.97, 27.63, 27.35, 27.10, 26.76; IR (thin film on a NaCl plate) 3006, 2918, 2846, 1654, 1437, 1403, 1348, 1312, 1240, 1158, 1101, 966, 845, 732 cm⁻¹.

Cross-linking of Bis(methacrylate)-functionalized Telechelic Poly(Butadiene)s (9)

In a 2 mL glass vial, polymer 9 (100 mg) was dissolved in toluene (200 μL) with either benzoyl peroxide or 2,2-dimethoxy-2-phenylacetophenone (2 mg, 2 wt %). This solution was then either subjected to heat in an oil bath at 90° C. (benzoyl peroxide-initiated) or light using a 450 watt medium pressure mercury Hanovia lamp (benzoyl peroxide- or 2,2-dimethoxy-2-phenylacetophenone-initiated) in a photolysis chamber. Although an insoluble material was formed within 5 min under these conditions for each of the different molecular weight polymers synthesized, heating or photolysis for 15 min resulted in a more highly cross-linked rubbery material which was completely insoluble in all common organic solvents including CH₂Cl₂, CHCl₃, benzene, toluene, Et₂O, ethyl acetate, and DMSO.

Cross-linking of Bis(epoxide)-functionalized Telechelic Poly(Butadiene)s (10)

In a 2 mL vial, polymer 10 (100 mg) was dissolved in toluene (500 μL) and a stir bar was added. This solution was then stirred at room temperature and H₂SO₄ (cat.) was added. Immediate formation of an insoluble rubbery solid was observed for each of the different molecular weight polymers synthesized. These materials were completely insoluble in all common organic solvents including CH₂Cl₂, CHCl₃, benzene, toluene, Et₂O, ethyl acetate, and DMSO. 

What is claimed is:
 1. A linear polymer of the general formula

wherein: n is an integer;

 is an alkadienyl group; Y is an alkyl group; and, Z is methacrylate or epoxide.
 2. A linear polymer of the general formula

wherein n is an integer and Z is a crosslinkable end group.
 3. The polymer as in claim 2 wherein Z is selected from the group consisting methacrylate, acylate, cinnamate, epoxide, lactone, cyclic carbonate, tetrahydrofuran, oxetane, lactams, phosphazenes, and alkoxysilanes.
 4. The polymer as in claim 3 wherein Z is methacrylate or epoxide. 